This study sought to examine computer application skill and lecturers’ Job effectiveness: a way of corruption elimination in university of Calabar, Cross River State, Nigeria. Literature review was both empirical and theoretical. The design used was causal comparative (Ex-Post-Facto). One research question and a null hypothesis formulated to direct the investigation. The population of the study was 1856, from the University of Calabar (UNICAL). The instrument for data collection was constructed by the researchers using a four likert scale questionnaire titled; Computer Application Skill and Lecturers’ Job Effectiveness Questionnaire (CASLJEQ). The face and content validity was checked by experts in Educational Psychology, Measurement and Evaluation who vetted the items developed. The reliability of the instrument was trial tested using the Cronbach Alpha method and the co-efficient was found to be .76. The stratified random sampling technique was used to sample 343 lecturers, for the study. Statistical tool employed for data analysis was simple percentage to answer the research question and Pearson Product Moment Correlation to test the hypothesis at 0.05 level of significance, with 341 degree of freedom. The result of the analysis revealed that computer application skill significantly relate with lecturers’ Job effectiveness. It was recommended that regular seminars and workshops on Computer application skill be organized for academics to update and sustain their skills in research.