We wanted to assess how much would be the impact of a multilevel treatment with dietary supplements derived from purified natural nutrients and life style changes on symptoms related to constipation predominant irritable bowel syndrome(IBS). 21 naïve female patients, age=41,55±16,92 years, nonsmokers, non lactose intolerant, without proven food allergies, diagnosed with predominant constipation IBS according to Rome II criteria, joined a nonrandom open label pilot study. We assessed main symptoms using Mc Gill questionnaires part A and B and a Hydrogen expiratory test was performed before and after the treatment. After therapy differences were statistically significant for bowel habit, flatulence, bloating, incomplete evacuation and global status scores and not statistically significant for abdominal pain scoring. Hydrogen values measured at 15,30,60 and 120 minutes changed significantly after the treatment. In conclusion prebiotics, probiotics and activated charcoal associated to life style changes mitigated most of our female patients symptoms related to IBS.